
10th Convocation Report 2022
Indian Institute of Technology Indore | 151
of Chemistry and Department of Biosciences and Biomedical Engineering at IIT Indore, is an Organic
Chemist and a Chemical Biologist. He was an Alexander von Humboldt Fellow during 2006-08 at Freie
University Berlin, Institute of Chemistry and Biochemistry with Prof. Hans-Ulrich Reissig and moved
to Purdue University, Department of Chemistry in 2012 to work with Prof. Philip S. Low in Chemical
Biology. In 2012 he was appointed as Assistant Professor in the Department of Chemistry and
promoted to Associate Professor in 2018 at the Indian Institute of Technology, Indore, India. His major
areas of interest are synthesis of anticancer natural products, diagnostic and therapeutic applications of
new targeting ligands for cancers, inflammatory and neurodegenerative diseases, synthesis of
inhibitors for drug targets, drug delivery systems, near-infrared fluorescence and nuclear radioisotopes
imaging, and bio-conjugate chemistry. His long-term goal is to establish a Centre of Excellence in the
field of chemical biology especially for the detection and treatment of cancer, inflammatory and
neurodegenerative diseases at IIT Indore. He has more than 15 years of experience in carrying out in
vitro, in vivo mouse, and rat models on various diseases like cancer, arthritis, and inflammatory
diseases.
Details of Patents filled/awarded:
1)Third-generation tubulysin analogues and process of preparation thereof, Venkatesh, C., Venkatesh,
C., Pandit, A., Ramesh B. Reddy, B.R., Yadav, K., Roy, D., Pathak, B. March 2021, USA patent,
Application No. 17/198,918.
2) Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications,
Venkatesh, C., Dudhe, P., Krishnan, M. A., Sonawane, A., 2020, USA patent, Application no. 16931838.
Details of Projects active:
1) Ligand Targeted NIR Dye/Fe3O4 Nanoconjugates for dual (Optical/MRI) Imaging and
Hyperthermia to treat Metastatic Castration Resistant Prostate Cancer, DAAD, 2019-2023;
2) Design, Synthesis and Biological Evaluation of Bcr-Abl Inhibitors Active Against Wild and Mutant
Bcr-Abl Tyrosine Kinases, DST-SERB, 2020-2023;
3) Indigenous Targeted Radiopharmaceuticals for Detection and Therapy of Prostate Malignancy, DBT-
BIRAC, 2020-2022; 4) Development of Novel Benzo fused Heterocycles to Improve the Treatment of
Drug Resistant Tuberculosis, DBT, 2021-2022
Total number of Books published/under process: Revolutionising medical diagnosis with SPECT
imaging: Clinical applications of a nuclear imaging technology, Krishnan, M.A., Cherukumudi, A.,
Oommen, S., Suresh Malapure, S., Chelvam, V., Elsevier Science Publishing Company, Inc. 2021
Total number of Journal Articles published/under process:
1. In vitro and in vivo evaluation of targeted fluorescent imaging agents for diagnosis and resection of
cancer, Curr. Protoc. Chem. Biol. 0, 00, (2022). 2. Multifaceted regulation of UBE2C by LIMK2 drives
castration-resistant prostate cancer, Bray, E., Krishnan, M. A., Venkatesh, C., Shah, K., Cancer, 0, 00,
(2022) (in revision).
3. Optimizing affinity to prostate-specific membrane antigen by spacer modifications in a tumor
spheroid model, Krishnan, M.A.,Pandit, A., Sharma, R., Venkatesh, C., J. Biomol. Struct. Dyn., June 27,
1–22, (2021).
4. Agarose micro-well platform for rapid generation of homogenous 3D tumor spheroids, Krishnan,
M.A., Yadav, K., Venkatesh, C., Curr. Protoc. Chem. Biol. 1(7), e199, (2021) (doi: 10.1002/cpz1.199).
5. Synthesis of 1-indolyl-3,5,8-substituted g-Carbolines: One-pot solvent-free protocol and biological
evaluation, Dudhe, P., Krishnan, M.A., Yadav, K., Roy, D., Venkatasubbaih, K., Pathak, B., Venkatesh,
C., Beilstein J. Org. Chem., 17, 1453–1463, (2021).
6. Folate-targeted verrucarin A reduces the number of activated macrophages in a mouse model of
acute peritonitis, Venkatesh, C., Doorneweerd, D.D., Xia, W., Putt, K.S., Low, P.S., Bioorg. Med. Chem.
Lett., 42, 128091, (2021).
7. Developing MicroSpherePlatform using a commercial hair brush: An agarose 3D culture platform
for deep-tissue imaging of prostate cancer, Krishnan, M.A., Venkatesh, C., ACS Appl. Bio. Mater. 5,
4254–4270, (2021).
8. Targeted QDot nanoprobe for early detection and surgical guidance of prostate cancer, Krishnan,
M.A., Yadav, K., Roach, P., Venkatesh, C., Biomater. Sci.
9, 2295–2312, (2021). 9. Evaluation of the reducing potential of PSMA-containing endosomes by FRET