
8. Origami Paper-based tecHnology fOr the
innovativE aNd sustaInable Organ-on-Chip devices-
PHOENIX-OoC
Description: Sustainability is one of the most important concepts nowadays,
being able to drive activities in several sectors, namely environment
preservation, society, and economy. In Analytical Chemistry, the development of
sustainable devices was boosted by the introduction of microfluidic paper-based
analytical devices (μPADs) whose advantages, however, are not only confined to
the concept of sustainability. Indeed, paper as a functional material, confers
unprecedented features to μPADs. However, paper-based devices remain
exploited as only analytical tools, but have not (yet) been adopted by the Organ-
on-Chip (OoC) world. The objective of the present project proposal is to alter
this scenario. PHOENIX-OoC, we will radically change the OoC field by making
use of paper’s versatile properties, and develop OoC devices using paper in
origami configuration used (i) for cell co-cultures with the aim to better simulate
different organ tissues, (ii) for (bio)sensors integration with the aim of on
site/continuous monitoring of cells status/response to stimuli, and (iii) with the
ultimate goal of performing accurate pharmacological studies. The main new
idea is the introduction of a technology which can deliver a versatile set of
electrochemical devices with new functionalities, in which, it will be possible to
create ready-to-use cell culture models for drug screenings, in a custom-made
manner. Because, OoC is a complex system with respect to μPADs, partners with
different and needed skills have been gathered among the most important
European scientists/entities in the field required. PHOENIX-OoC consortium
brings together 6 partners, 4 Universities, 1 research organization, and 1
industrial partner (1 SME), 5 from 4 EU (associated)countries (Italy, Sweden,
Spain, Serbia), and 1 non-EU member: Switzerland, which are renowned experts
in the world on paper-based biosensors, in vitro/vivo studies, modelling,
microfluidics, biomaterials, and joint tissue engineering.
Contact person: Prof. dr Goran Stojanović
Period of realization: 2024-2025
ID:
HORIZON-EIC-2023-PATHFINDEROPEN-01 (101130395)